Daclatasvir 60 mg Tablets are antiviral medicines used as part of combination treatment for chronic hepatitis C virus (HCV) infection. Daclatasvir is a direct-acting antiviral (DAA) that works against HCV and is commonly used with another antiviral medicine, particularly sofosbuvir, as part of an HCV treatment regimen. WHO recognizes sofosbuvir and daclatasvir as a pangenotypic DAA combination.
What Is Daclatasvir 60 mg?
Daclatasvir is an HCV NS5A inhibitor. The 60 mg strength is available as a film-coated tablet containing daclatasvir dihydrochloride equivalent to 60 mg of daclatasvir.
WHO's prequalification database includes 60 mg daclatasvir tablets from multiple manufacturers, demonstrating that this strength is used in internationally recognized HCV treatment programs.
How Is Daclatasvir Used in Hepatitis C Treatment?
Daclatasvir is generally not used alone to treat hepatitis C. It is combined with another direct-acting antiviral according to the patient's HCV infection, liver condition, previous treatment history, drug interactions and applicable treatment guidelines.
One established combination is daclatasvir 60 mg with sofosbuvir 400 mg. WHO has listed this combination as a pangenotypic regimen, meaning it can be used across different HCV genotypes under appropriate clinical guidance.
Treatment duration and the need for additional medicines can vary. Patients with cirrhosis, previous treatment experience or other medical conditions may require a different regimen.
How Does Daclatasvir Work?
Daclatasvir targets the HCV NS5A protein, which is important for viral replication and assembly. By interfering with this protein, daclatasvir helps prevent HCV from multiplying.
When used in combination with another antiviral such as sofosbuvir, medicines with different mechanisms of action work together to suppress the virus and support viral clearance.
Daclatasvir 60 mg Dosage and Administration
The appropriate dose and treatment duration should be determined by a qualified healthcare professional. The commonly used adult daclatasvir strength is 60 mg once daily, but the actual regimen depends on the accompanying antiviral medicine and the patient's clinical circumstances.
Patients should take the medicine exactly as prescribed and should not change the dose, stop treatment or combine it with other medicines without medical advice.
Important Drug Interactions
Before starting daclatasvir, patients should tell their healthcare provider about all prescription medicines, over-the-counter products and supplements they use.
Certain medicines can affect daclatasvir concentrations in the body. For this reason, reviewing current medications is an important part of selecting an appropriate HCV regimen.
Storage Information
Storage requirements depend on the specific manufacturer's product and packaging. For example, a WHO-prequalified 60 mg daclatasvir product specifies storage below 30°C. Always follow the storage conditions stated on the product packaging and manufacturer's approved information.
Daclatasvir 60 mg Tablets for Pharmaceutical Supply
Daclatasvir 60 mg is an established pharmaceutical product used in HCV treatment programs. WHO's prequalification records include several 60 mg daclatasvir products and a 60 mg/400 mg daclatasvir/sofosbuvir combination product.
For hospitals, pharmaceutical distributors, healthcare organizations and authorized medicine buyers, sourcing should include verification of the manufacturer's details, product strength, packaging, batch information, regulatory status and applicable import requirements.
Frequently Asked Questions
What are Daclatasvir 60 mg Tablets used for?
They are used as part of combination antiviral therapy for chronic hepatitis C infection.
Can Daclatasvir 60 mg be taken alone?
Daclatasvir is generally used in combination with other antiviral medicines rather than as monotherapy. The treatment combination should be selected by a healthcare professional.
Is Daclatasvir used with Sofosbuvir?
Yes. Daclatasvir and sofosbuvir have been used together as a pangenotypic HCV treatment regimen.
How long is hepatitis C treatment?
Treatment duration depends on the selected regimen and the patient's clinical condition. WHO notes that modern DAA treatment commonly uses short oral courses, with duration varying according to factors such as cirrhosis.
Is Daclatasvir 60 mg a prescription medicine?
Patients should use daclatasvir only under appropriate medical supervision and according to the regulatory requirements of their country.
Conclusion
Daclatasvir 60 mg Tablets are an important direct-acting antiviral option for hepatitis C treatment, particularly when used with other HCV medicines such as sofosbuvir. The correct treatment regimen depends on individual clinical factors, so patients should consult a qualified healthcare professional before starting therapy. For pharmaceutical procurement, buyers should verify product quality, regulatory documentation, packaging and import requirements before placing an order.