As the global demand for high-quality HIV antiretroviral therapy (ART) continues to grow, Tenofovir + Lamivudine + Efavirenz Tablets (TLE) remain an important treatment option in many healthcare programs, particularly where efavirenz-based regimens are still in use. While current WHO guidelines generally prefer dolutegravir-based regimens, TLE continues to be used in specific clinical settings and national treatment programs.
Mechanism of Action (MOA)
Tenofovir Disoproxil Fumarate (TDF)
A Nucleotide Reverse Transcriptase Inhibitor (NtRTI).
Blocks HIV reverse transcriptase, preventing viral DNA synthesis and reducing HIV replication.
Lamivudine (3TC)
A Nucleoside Reverse Transcriptase Inhibitor (NRTI).
Inhibits reverse transcriptase, stopping HIV from multiplying inside human immune cells.
Efavirenz (EFV)
A Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI).
Directly binds to HIV-1 reverse transcriptase, altering the enzyme's function and preventing viral replication.
Combined Effect
The triple-drug combination:
Suppresses HIV viral load
Helps increase CD4 cell count
Reduces the risk of HIV progression to AIDS
Improves long-term treatment outcomes when taken consistently under medical supervision.
Uses of Tenofovir + Lamivudine + Efavirenz Tablets
HIV-1 infection treatment
Combination Antiretroviral Therapy (ART)
Long-term viral suppression
Prevention of HIV disease progression
Used in selected national HIV treatment programs where efavirenz-based regimens remain indicated
Note: Current WHO recommendations generally favor dolutegravir-based regimens for most newly initiated patients, although efavirenz-containing regimens continue to have roles in certain settings.
Global Export Markets
Cordium Pharmaceuticals Pvt. Ltd. supplies quality-assured Tenofovir + Lamivudine + Efavirenz Tablets to international pharmaceutical buyers, government tenders, NGOs, hospitals, and distributors across:
🇰🇪 Kenya
🇳🇬 Nigeria
🇬🇭 Ghana
🇵🇭 Philippines
🇻🇳 Vietnam
🇦🇪 UAE
🇸🇦 Saudi Arabia
🇺🇿 Uzbekistan
🇰🇿 Kazakhstan
🇺🇸 USA
🇬🇧 UK
🇿🇦 South Africa
Why Choose Cordium Pharmaceuticals Pvt. Ltd.?
✔ WHO-GMP Manufacturing Standards
✔ International Export Documentation
✔ Bulk Supply & Third-Party Manufacturing
✔ Competitive Global Pricing
✔ Reliable Pharmaceutical Export Partner
✔ Regulatory Support for International Markets
