INSTGRA Tablets: Active Ingredient, Strengths, Uses, Benefits, Side Effects and FAQs in Singapore

INSTGRA Tablets are an antiretroviral medicine used in the management of human immunodeficiency virus type 1 (HIV-1) infection. The product is marketed by Emcure Pharmaceuticals Ltd. in India. It is intended to be used under medical supervision as part of an appropriate HIV treatment regimen.

The active ingredient in INSTGRA Tablets is dolutegravir, an integrase strand transfer inhibitor (INSTI). It works by blocking an HIV enzyme required for the virus to integrate its genetic material into human cells, helping control viral replication.

For individuals searching for INSTGRA Tablets in Singapore, it is important to confirm the product's local registration status and availability with an authorised healthcare professional or the Health Sciences Authority (HSA).

INSTGRA Tablets: Active Ingredient and Strengths

Brand name: INSTGRA

Active ingredient: Dolutegravir

Commonly listed strength: 50 mg per tablet

Dosage form: Oral tablet

Manufacturer/marketer: Emcure Pharmaceuticals Ltd.

Therapeutic category: Antiretroviral medicine (integrase inhibitor)

Primary use: Management of HIV-1 infection in combination with other appropriate antiretroviral medicines

Product strengths, packaging and availability can vary by market. Always verify the strength printed on the original packaging and the approved product information before use.

Uses and Benefits of INSTGRA Tablets

1. Helps Control HIV Infection

Dolutegravir inhibits HIV integrase, an enzyme involved in viral replication. When taken as prescribed with an appropriate combination of antiretroviral medicines, it helps reduce the amount of HIV in the bloodstream.

2. Supports Viral Suppression

Consistent treatment can help achieve and maintain viral suppression. The response to therapy depends on adherence, resistance patterns, other medicines and individual health factors.

3. Helps Preserve Immune Function

Effective HIV treatment can help protect the immune system and reduce the risk of HIV-related complications over time.

4. Supports Long-Term HIV Management

INSTGRA may form part of a long-term treatment plan supervised by an HIV specialist. It is not a cure for HIV, and patients should continue treatment and monitoring as directed by their healthcare team.

Possible Side Effects of INSTGRA Tablets

Like other medicines, INSTGRA may cause side effects. Commonly reported effects associated with dolutegravir include:

Headache

Nausea

Diarrhoea

Difficulty sleeping

Fatigue or dizziness

Some people may experience mood changes or depressive symptoms. Rare but serious reactions can include severe allergic reactions or liver problems.

Seek urgent medical attention for difficulty breathing, facial or throat swelling, a severe rash, yellowing of the skin or eyes, or other serious symptoms. Contact your doctor if side effects persist or become troublesome.

Precautions and Safe Use

Take INSTGRA only when prescribed by a qualified healthcare professional. Do not change the dose, stop treatment or substitute another HIV medicine without medical advice.

Tell your doctor about all medicines and supplements you take. Dolutegravir can interact with certain antacids, mineral supplements, metformin and other medicines. Some combinations require dose adjustments, separation of administration times or avoidance.

Your healthcare professional may recommend HIV viral-load monitoring, liver-function tests and other assessments. Discuss pregnancy, breastfeeding, kidney or liver conditions, and any previous HIV treatment or resistance with your doctor.

Frequently Asked Questions (FAQs)

What is the active ingredient in INSTGRA Tablets?

INSTGRA Tablets contain dolutegravir, an antiretroviral medicine that belongs to the integrase inhibitor class.

What strength of INSTGRA Tablets is available?

The commonly listed product is INSTGRA 50 mg. Confirm the exact strength and formulation against the manufacturer's packaging and current product documentation.

What are INSTGRA Tablets used for?

They are used as part of combination antiretroviral therapy to manage HIV-1 infection. They do not cure HIV.

What are the common side effects?

Headache, nausea, diarrhoea, fatigue and sleep difficulties may occur. Consult your healthcare professional about persistent or serious symptoms.

Can I buy INSTGRA Tablets in Singapore?

Availability depends on local regulatory approval and authorised supply arrangements. Check the Singapore HSA's official product information resources and consult a licensed healthcare professional before purchasing.

Is INSTGRA suitable for everyone with HIV?

No. Treatment suitability depends on individual medical history, previous treatment, resistance results, other medicines and clinical assessment.

Important Medical and Regulatory Notice

This page is for general educational purposes and is not a substitute for professional medical advice. Product information should be reviewed against the current manufacturer-approved leaflet .