Regorafenib Tablets in Singapore | Uses, Safety & FAQs

Regorafenib tablets are an oral targeted cancer medicine prescribed for certain adults with advanced cancers. Regorafenib belongs to a class of medicines known as multikinase inhibitors. It works by blocking specific proteins involved in cancer cell growth and the formation of blood vessels that supply tumours.

In Singapore, regorafenib is used for selected patients with metastatic colorectal cancer, gastrointestinal stromal tumours (GIST) and hepatocellular carcinoma (HCC), depending on the approved indication and previous treatments received. It is a prescription-only medicine and requires specialist medical supervision. Source: Singapore National Drug Formulary.

Benefits and Uses of Regorafenib Tablets

Regorafenib may offer clinical benefits for eligible patients whose cancer has progressed following other treatments. Its potential uses include:

Metastatic colorectal cancer: May be prescribed to eligible adults whose disease has progressed after specified standard treatments.

Gastrointestinal stromal tumours (GIST): May be used for advanced or metastatic GIST after previous targeted therapies, according to the applicable product indication.

Hepatocellular carcinoma (HCC): May be considered for certain patients with liver cancer who have previously received sorafenib, subject to clinical assessment and approved prescribing guidance.

Regorafenib inhibits several protein kinases involved in tumour growth and angiogenesis. Its clinical role is to help manage specific advanced cancers; it is not a cure for cancer, and individual responses vary. Source: Singapore National Drug Formulary.

Regorafenib Tablets: Side Effects and Precautions

Like other targeted cancer medicines, regorafenib can cause side effects. Commonly reported effects include:

Fatigue and weakness

Diarrhoea and abdominal discomfort

Nausea and reduced appetite

Mouth ulcers

High blood pressure

Dryness, redness, pain or peeling of the palms and soles

Hoarseness or changes in voice

Serious risks: Regorafenib can cause severe liver injury, bleeding, heart problems and other serious complications. Seek urgent medical attention for yellowing of the skin or eyes, dark urine, unusual bleeding, chest pain, breathing difficulties or severe abdominal pain.

Patients may require regular liver function tests and blood pressure monitoring. Inform the treating doctor about existing medical conditions, pregnancy plans, upcoming surgery and all medicines or supplements being taken. Avoid grapefruit and grapefruit juice during treatment unless a healthcare professional advises otherwise.

Take regorafenib only as prescribed. The dose and treatment schedule must be determined by the treating specialist. Source: Singapore HealthHub.

Frequently Asked Questions (FAQs)

1. What are Regorafenib tablets used for?

They are used to treat selected cases of metastatic colorectal cancer, advanced GIST and hepatocellular carcinoma, depending on previous treatment and the approved indication.

2. Are Regorafenib tablets available in Singapore?

Regorafenib products are listed in Singapore's National Drug Formulary. Availability of a specific brand or presentation may vary. Check with a licensed healthcare provider or pharmacist.

3. Can I buy Regorafenib tablets online in Singapore?

Regorafenib is a prescription-only medicine. Consult a licensed healthcare professional and use authorised supply channels. Verify the product's Singapore registration and import requirements before purchasing.

4. What are the common side effects of Regorafenib?

Common side effects include fatigue, diarrhoea, nausea, mouth ulcers, high blood pressure and hand-foot skin reactions. Serious symptoms require prompt medical assessment.

5. Does Cordium Pharmaceuticals Pvt Ltd supply Regorafenib in Singapore?

Contact Cordium Pharmaceuticals Pvt Ltd directly to enquire about product availability, documentation and international supply arrangements. Singapore registration and import eligibility must be independently verified.

Contact Cordium Pharmaceuticals Pvt Ltd

For pharmaceutical product information and business enquiries, contact Cordium Pharmaceuticals Pvt Ltd through its official communication channels.

Medical Disclaimer: This content is for educational and pharmaceutical information purposes only. It does not replace professional medical advice, diagnosis or treatment. Regorafenib must be used under appropriate specialist supervision. Always consult the approved product information and Singapore's Health Sciences Authority requirements before prescribing, supplying or importing this medicine.