Rybelsus® 3mg, 7mg & 14mg Tablets (Semaglutide)

Oral Treatment for Type 2 Diabetes Management

Rybelsus is a prescription medicine containing semaglutide, a GLP-1 receptor agonist used alongside diet and exercise to improve blood sugar control in adults with Type 2 diabetes. It is the first oral form of semaglutide available as a once-daily tablet.

Rybelsus is available in three strengths:

Rybelsus 3mg tablets

Rybelsus 7mg tablets

Rybelsus 14mg tablets

It is prescribed as part of a dose escalation schedule to improve tolerability and reduce gastrointestinal side effects.

What Is Rybelsus Used For?

Rybelsus is indicated for adults with Type 2 diabetes mellitus to:

Improve blood glucose (blood sugar) control alongside diet and exercise.

Reduce the risk of major cardiovascular events in certain adults with Type 2 diabetes who are at high cardiovascular risk (depending on local regulatory approvals).

Rybelsus is not approved for:

Type 1 diabetes

Diabetic ketoacidosis

General weight loss treatment without a healthcare provider's supervision

How Does Rybelsus Work?

Rybelsus contains semaglutide, which mimics the natural GLP-1 hormone in the body.

It works by:

Stimulating insulin release when blood sugar is high

Reducing excess glucose production by the liver

Slowing stomach emptying

Helping control appetite and food intake

Rybelsus Dosage Guide

Strength Typical Use Duration

3mg Starting dose First 30 days

7mg Maintenance dose After day 30

14mg Higher maintenance dose if additional glucose control is needed After at least 30 days on 7mg

Important: The 3mg tablet is an initiation dose and is not intended to provide full blood sugar control on its own.

Your healthcare provider will determine the appropriate dose based on your treatment response.

How to Take Rybelsus Tablets

Take Rybelsus exactly as prescribed.

Instructions:

Take once daily in the morning.

Take on an empty stomach.

Swallow the tablet whole with no more than 120 mL (4 oz) of plain water.

Wait at least 30 minutes before eating, drinking, or taking other oral medications.

Do not split, crush, or chew the tablet.

If you miss a dose, skip it and take the next scheduled dose the following day.

Benefits of Rybelsus

Rybelsus may help:

✅ Lower HbA1c levels

✅ Improve daily blood sugar control

✅ Support weight reduction in some patients

✅ Offer an oral alternative to injectable GLP-1 medications

✅ Support cardiovascular risk reduction in eligible adults

Common Side Effects

The most common side effects include:

Nausea

Diarrhea

Abdominal pain

Vomiting

Constipation

Decreased appetite

These side effects are usually more common when treatment is first started and may improve over time.

Important Safety Information

Do not take Rybelsus if:

You or a family member has a history of medullary thyroid carcinoma (MTC)

You have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

You are allergic to semaglutide or any ingredient in the medicine

Seek medical attention immediately if you experience:

Severe abdominal pain (possible pancreatitis)

Severe allergic reactions

Vision changes

Symptoms of gallbladder problems

Persistent nausea, vomiting, or dehydration

Frequently Asked Questions (FAQs)

Is Rybelsus used for weight loss?

Rybelsus is primarily approved for Type 2 diabetes treatment. Some patients may experience weight loss, but it should only be used according to a doctor's prescription.

Can I take Rybelsus with other diabetes medicines?

Yes. Your healthcare provider may prescribe it alone or with other diabetes medications, depending on your treatment plan.

Can I split a Rybelsus tablet?

No. Tablets should be swallowed whole and should not be split, crushed, or chewed.

Disclaimer

Prescription Only Medicine. This information is for educational purposes only and does not replace professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication.