Yupelri (Revefenacin 175 mcg/3 mL)

Advanced Once-Daily Maintenance Treatment for Chronic Obstructive Pulmonary Disease (COPD)

Yupelri® (Revefenacin 175 mcg/3 mL) is a once-daily long-acting muscarinic antagonist (LAMA) indicated for the maintenance treatment of Chronic Obstructive Pulmonary Disease (COPD). It is supplied as a ready-to-use inhalation solution administered via a standard jet nebulizer, making it particularly beneficial for patients who have difficulty using handheld inhalers.

Its prolonged bronchodilatory effect helps improve airflow, reduce symptoms, and decrease COPD exacerbations while enhancing patients' quality of life.

What is Revefenacin?

Revefenacin is a long-acting anticholinergic bronchodilator (LAMA) that works by blocking muscarinic receptors in the airway smooth muscle.

This action:

Relaxes bronchial muscles

Opens narrowed airways

Improves airflow

Reduces breathlessness

Helps prevent COPD flare-ups

Supports improved lung function throughout the day

Unlike rescue inhalers, Revefenacin is designed for daily maintenance therapy and not for immediate relief of acute bronchospasm.

Indications

Yupelri is indicated for:

Maintenance treatment of COPD

Chronic bronchitis associated with COPD

Emphysema

Long-term bronchodilator therapy

Patients unable to effectively use inhaler devices

Elderly COPD patients requiring nebulized treatment

Benefits of Yupelri

Once-Daily Therapy

Provides 24-hour bronchodilation with a single daily dose.

Nebulized Delivery

Ideal for patients with poor inhaler coordination.

Improved Lung Function

Helps increase airflow and reduce airway obstruction.

Better Symptom Control

Reduces:

Wheezing

Breathlessness

Chest tightness

Persistent cough

Enhanced Quality of Life

Supports improved exercise tolerance and daily activities.

Convenient Administration

Ready-to-use solution requiring no dilution.

Mechanism of Action

Revefenacin selectively blocks M3 muscarinic receptors in airway smooth muscle.

This results in:

Reduced cholinergic bronchoconstriction

Relaxation of bronchial smooth muscle

Sustained bronchodilation

Improved respiratory function

Because of its lung-selective activity, systemic anticholinergic effects are minimized.

Dosage & Administration

Recommended Dose

175 mcg (3 mL) inhaled once daily

Administration:

Use only with a standard jet nebulizer connected to an air compressor.

Do not swallow or inject.

Administer at the same time each day.

Do not mix with other nebulized medicines unless directed by a healthcare professional.

Who Can Benefit?

Yupelri may be suitable for:

Adults with moderate COPD

Severe COPD patients

Elderly patients

Patients with poor inhaler technique

Individuals requiring nebulized maintenance therapy

Patients with chronic airflow limitation

Possible Side Effects

Common adverse effects may include:

Cough

Nasopharyngitis

Upper respiratory tract infection

Headache

Back pain

Less common but potentially serious effects:

Urinary retention

Narrow-angle glaucoma symptoms

Hypersensitivity reactions

Paradoxical bronchospasm

Patients should seek medical attention if severe allergic reactions or breathing difficulties occur.

Precautions

Use with caution in patients with:

Narrow-angle glaucoma

Prostatic hyperplasia

Bladder outlet obstruction

Severe renal impairment

Pregnancy or breastfeeding (consult a healthcare provider)

Not intended for:

Acute asthma attacks

Rescue treatment

Pediatric use unless specifically recommended

Drug Interactions

Healthcare professionals should review concomitant medications, particularly:

Other anticholinergic medicines

COPD combination therapies

Bronchodilators

Prescription and over-the-counter medications

Herbal supplements

Storage Instructions

Store according to manufacturer recommendations.

Keep vials in their protective pouch until use.

Protect from excessive heat and light.

Keep out of reach of children.

Do not use expired or damaged vials.

Why Healthcare Professionals Choose Yupelri

Healthcare providers value Yupelri because it offers:

Once-daily dosing

Effective bronchodilation

Nebulized administration

Improved patient adherence

Consistent lung function improvement

Suitable option for patients unable to use handheld inhalers

International Supplier of Yupelri (Revefenacin)

We support international pharmaceutical sourcing for healthcare providers, distributors, hospitals, and licensed importers.

USA

Reliable pharmaceutical export support for licensed buyers seeking respiratory therapies and COPD maintenance medications.

United Kingdom (UK)

Supply assistance for wholesalers, hospital procurement teams, and authorized pharmaceutical distributors.

United Arab Emirates (UAE)

Supporting pharmaceutical imports through compliant documentation and dependable international logistics.

South Africa

Serving hospitals, pharmacies, and licensed distributors with export-ready respiratory products.

Why Partner With Us?

We provide:

International pharmaceutical exports

Competitive wholesale pricing

Secure packag